HIV is a lifelong, life-altering condition that requires ongoing treatment and monitoring. One of the common treatments for HIV is antiretroviral therapy (ART), which consists of a combination of four or more drugs. ART helps patients manage their HIV by effectively reducing the amount of virus in their body and suppressing its replication. Although this treatment is effective and lifesaving for many, it can lead to long-term side effects on certain organs, such as the kidneys.

Kidney toxicity has long-term effects

Kidney toxicity is one of the long-term effects of some HIV medicines. Protease inhibitors, which are a type of ART drug, can cause elevations in the levels of creatinine, a waste product that is normally removed from the body by the kidneys. If these levels are too high, it can be an indication of reduced kidney function due to the inability to excrete creatinine. These high levels of creatinine can lead to an increased risk of kidney stones and other problems.

Increase in the level of other modulatory factors

In addition, HIV-related kidney complications may be made worse by ART treatment. HIV itself can lead to kidney inflammation, a condition known as HIV proteinuria, which can also lead to kidney damage if left untreated. ART drugs may further increase the levels of inflammation and damage in the kidneys, leading to further kidney problems.

Reduction with deterioration in kidney function over time

Additional long-term effects of ART drugs on the kidneys include a higher risk of developing chronic kidney disease (CKD). This is often seen in older adults who have been taking ART drugs for extended periods of time, as the drugs reduce their kidney function over time. HIV proteins can also accumulate in the kidneys due to reduced kidney function. This can lead to a buildup of proteins in the urine, which can further cause inflammation and injury to the kidneys.

To prevent and protect the vital function of the kidneys

Patients taking ART drugs for HIV should be aware of the potential long-term effects on their kidneys and should discuss this with their doctor. Regular blood tests should be performed to check for increased creatinine levels, indicating reduced kidney function. Kidney function should also be assessed on a regular basis to monitor for further issues. Regular exercise and following a healthy diet may help to protect against kidney damage from ART drugs. In addition, patients should contact their doctor if they experience any signs or symptoms of kidney damage including fatigue, proteinuria, edema, confusion, or decreased urination.

Medicine – Dolutegravir

Dolutegravir is an antiviral medicine commonly used to treat HIV or human immunodeficiency virus. It works by blocking reverse transcriptase, an enzyme needed for the virus to replicate and grow. Developed by Gilead Sciences in 2013, dolutegravir 50mg has become a highly successful first-line therapy for HIV treatment due to the drug’s low rate of side effects and its ability to reduce viral loads quickly. 

The drug also offers better outcomes than most other antiviral drugs, with clinical trials demonstrating significant decreases in mortality and resistance rates among patients taking dolutegravir. Additionally, it is usually prescribed as part of combination therapy with other anti-HIV drugs as this increases efficacy and prevents drug resistance. All in all, dolutegravir is a reliable and effective treatment option for those suffering from HIV and related illnesses.


In conclusion, HIV drugs can lead to long-term kidney damage and complications. Patients taking ART should discuss the potential risks with their doctor and get regular blood tests and kidney assessments. Following a healthy lifestyle and seeking medical advice as soon as possible if any symptoms of kidney damage arise can help to reduce the risk of long-term complications.

Previous articleTreatment of Lung Cancer with Alectinib
Next articleA Guide to Finding the Best Irish Whiskey on TheSingleMaltShop
Oliver James is a UK-based professional blogger, content writer, and content marketer who writes about travel and tourism, finance, real estate, and other topics on his blog. Passionate about writing, traveling, and getting the best deal on everything he buys, Oliver also writes for customers and helps them publicize their products, and services in the US and UK markets. He is a traveler who has visited over 35 countries and loves his job because it gives him the opportunity to find stories, experiences, and places which he can share with his readers. Oliver James is a professional blogger, content marketer, traveler, and electronics enthusiast. He started blogging in 2016 and has become a contributing writer for several blogs, including Android Authority and Elecpros. Oliver has also published his own informational books with Kindle Direct Publishing on subjects like Flappy Bird and Google Cardboard. Also Read: > all inclusive holidays > Lumber Takeoff Services We are Content Writing Agency Australia. We are a team of creative writers, passionate storytellers, and dedicated content creators committed to producing high-quality written pieces that capture your business’s unique voice. Our mission is to provide engaging, meaningful content that resonates with your target audience and helps you reach your goals. Tech Articles Sample: macOS Ventura | Sony Xperia 1 IV | iPhone 14 VS iPhone 14 Pro | iPhone 13 VS iPhone 14 Educational Articles Sample: Radio communication protocols | Create computer software | Difference between Deep web & Dark web | Difference between software & an app | Blackboard DCCCD Sport Articles Sample: Carrom History | Swimming History | Arnis History | Dog Surfing History | Extreme Ironing History | Sepak Takraw History Kate Johnson is a content writer, who has worked for various websites and has a keen interest in Online Signals Report and Stock portfolio generator. She is also a college graduate who has a B.A in Journalism. Read More: Fin Scientists >> Read More: Stocks Signals Mobile App >> Read More: Crypto Signals >> Read More: Crypto Trade Signals App >> Read More: Trade Signal Buy and Sell